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KMID : 0376119920190010099
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Medical Journal of the Red Cross Hospital
1992 Volume.19 No. 1 p.99 ~ p.106
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Levels of Serum Soluble Interleukin-2 Receptor(IL-2R) in Patients with Burn
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Abstract
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Cell-mediated immunity frequently becomes severely impaired after burn. However, the cause of postburn immune dysfunction is unclear and controversy exists over both pathophysiology and clinical relevance of these abnormalities.
This study was undertaken to investigate the immune response in vivo of patients with burn. Levels of soluble IL-2R, a sensitive marker of T-cell activation, were measured in 26 patients with burn.
Serum soluble IL-2R levels in patients with burn were significantly higher than those of normal controls. The burn patients were classified according to the outcome. Patients with fatal outcome always showed a higher soluble IL-2R levels than
survivors.
Postburn sera significantly suppressed mitogen-induced lymphocyte proliferation.
These data indicate that soluble IL-2R might be useful parameters for monitoring of the clinical course in burn patients.
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KEYWORD
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